is leukocyte telomere length related with lung cancer risk?: a meta-analysis

نویسندگان

behrooz karimi department of environmental health engineering, school of public health, tehran university of medical sciences, enghelab st., tehran, iran

masud yunesian department of environmental health engineering, school of public health, tehran university of medical sciences, enghelab st., tehran, iran

ramin nabizadeh department of environmental health engineering, school of public health, tehran university of medical sciences, enghelab st., tehran, iran

parvin mehdipour department of medical genetics, school of medicine, tehran university of medical sciences, enghelab st., tehran, iran

چکیده

background: epidemiological studies have probed the correlation between telomere length and the risk of lung cancer, but their findings are inconsistent in this regard.  the present meta-analysis study has been carried out to demonstrate the association between relative telomere length in peripheral blood leukocytes and the risk of lung cancer using an established q-pcr technique. methods: a systematic search was carried out using pubmed, embase, and isi before 2015. a total of 2925 cases of lung cancer and 2931 controls  from 9 studies were  employed to probe the relationship between lung cancer and telomere length .ors were used at 95% ci. random-effects models were used to investigate this relationship based on the heterogeneity test. heterogeneity among studies was analyzed employing subgroup analysis based on type studies and the year of publication. results: random-effects meta-analysis revealed that patients with lung cancer were expected to have shorter telomere length than the control (1.13, 95% ci: 0.82-1.81, p=0.46). the summary of the pooled ors of telomere length in adenocarcinoma lung cancer patients was 1 (95%ci=0.68-1.47, i2=93%) compared to patients with squamous cell lung cancer, which was 1.78 (95% ci=1.25-2.53, i2=3.9%). the meta-regression revealed that the effect of telomere length shortening, decreased and increased with the year of publication and the age of risks to lung cancer, was clearly related to short telomeres lengths. conclusion: lung cancer risks clearly related with short telomeres lengths. in patients with breathing problems, lung cancer risk can be predicted by telomere length adjustment with age, sex, and smoking.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Is Leukocyte Telomere Length Related with Lung Cancer Risk?: A Meta-Analysis

Background: Epidemiological studies have probed the correlation between telomere length and the risk of lung cancer, but their findings are inconsistent in this regard.  The present meta-analysis study has been carried out to demonstrate the association between relative telomere length in peripheral blood leukocytes and the risk of lung cancer using an established Q-PCR technique. Methods:...

متن کامل

Is Leukocyte Telomere Length Related with Lung Cancer Risk?: A Meta-Analysis

BACKGROUND Epidemiological studies have probed the correlation between telomere length and the risk of lung cancer, but their findings are inconsistent in this regard. The present meta-analysis study has been carried out to demonstrate the association between relative telomere length in peripheral blood leukocytes and the risk of lung cancer using an established Q-PCR technique. METHODS A sys...

متن کامل

Leukocyte telomere length in patients with schizophrenia: A meta-analysis.

Schizophrenia has been suggested as a syndrome of accelerated aging. Telomere length (TL) decrease is considered one biological marker associated with age and can be accelerated by pathological characteristics present in schizophrenia. Several studies evaluated TL in schizophrenia, but the results are still controversial. The aim of this study was to conduct a meta-analysis of the existing resu...

متن کامل

Leukocyte telomere length and hippocampus volume: a meta-analysis

Leukocyte telomere length has been shown to correlate to hippocampus volume, but effect estimates differ in magnitude and are not uniformly positive. This study aimed primarily to investigate the relationship between leukocyte telomere length and hippocampus gray matter volume by meta-analysis and secondarily to investigate possible effect moderators. Five studies were included with a total of ...

متن کامل

Shortened Telomere Length Is Associated with Increased Risk of Cancer: A Meta-Analysis

BACKGROUND Telomeres play a key role in the maintenance of chromosome integrity and stability, and telomere shortening is involved in initiation and progression of malignancies. A series of epidemiological studies have examined the association between shortened telomeres and risk of cancers, but the findings remain conflicting. METHODS A dataset composed of 11,255 cases and 13,101 controls fr...

متن کامل

Leukocyte Telomere Length and Cancer Risk: A Dynamic Problem

Telomeres are the protective structure at both ends of each chromoThe decelerating age-adjusted LTL attrition in cancer cases as they some. Telomere length is widely considered a marker of biological aging. For convenience, telomere lengths in human population studies have been predominately measured in peripheral blood leukocytes. Although leukocyte telomere length (LTL) is generally inversely...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید


عنوان ژورنال:
iranian biomedical journal

جلد ۲۱، شماره ۳، صفحات ۱۴۲-۱۵۳

کلمات کلیدی

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023